ALL dataset: Differentially expressed genes between BCR/ABL and NEG B-cell ALL

Probe Symbol Description Function Chromosome Chromosome Location GenBank LocusLink Cytoband UniGene PubMed Gene Ontology Pathway Test statistic Adjusted p-value
1635_at ABL1 v-abl Abelson murine leukemia viral oncogene homolog 1   9 130740384, 130618821 U07563 9q34.1 Hs.431048 160

regulation of progression through cell cycle

S-phase-specific transcription in mitotic cell cycle

nucleotide binding

DNA binding

protein-tyrosine kinase activity

protein binding

ATP binding

nucleus

mismatch repair

regulation of transcription, DNA-dependent

protein amino acid phosphorylation

intracellular signaling cascade

DNA damage response, signal transduction resulting in induction of apoptosis

transferase activity

Cell cycle

8.44066 0
40202_at KLF9 Kruppel-like factor 9   9 -70229068 D31716 9q13 Hs.150557 8

transcription factor activity

nucleus

transcription

regulation of transcription from RNA polymerase II promoter

zinc ion binding

metal ion binding

  6.33086 0
37027_at AHNAK AHNAK nucleoprotein (desmoyokin)   11 -62039950, -61957591 M80899 11q12.2 Hs.502756 10

nucleus

neurogenesis

  5.70936 0.0014
39837_s_at ZNF467 zinc finger protein 467   7 -148899099 AC004877 7q36.1 Hs.112158 2     5.45029 0.0034
33774_at CASP8 caspase 8, apoptosis-related cysteine peptidase   2 201923686, 201948284, 201950747, 201923693 X98172 2q33-q34 Hs.369736 172

signal transducer activity

mitochondrion

cytoskeleton

proteolysis and peptidolysis

cysteine-type peptidase activity

apoptotic program

caspase activity

protein self binding

regulation of apoptosis

positive regulation of I-kappaB kinase/NF-kappaB cascade

Neurodegenerative Disorders

MAPK signaling pathway

Apoptosis

Toll-like receptor signaling pathway

Huntington's disease

Dentatorubropallidoluysian atrophy (DRPLA)

5.28995 0.0042
2039_s_at FYN FYN oncogene related to SRC, FGR, YES   6 -112089177, -112089179 M14333 6q21 Hs.390567 154

nucleotide binding

protein-tyrosine kinase activity

protein binding

ATP binding

protein amino acid phosphorylation

protein kinase cascade

learning

feeding behavior

transferase activity

Focal adhesion

Adherens junction

T cell receptor signaling pathway

5.21021 0.005
37014_at MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)   21 41720023 M33882 21q22.3 Hs.517307 35

nucleotide binding

GTPase activity

GTP binding

cytoplasm

induction of apoptosis

immune response

signal transduction

response to virus

  -5.22563 0.005
39329_at ACTN1 actinin, alpha 1   14 -68410792 X15804 14q24.1-q24.2|14q24|14q22-q24 Hs.509765 33

actin binding

structural constituent of cytoskeleton

calcium ion binding

actin cytoskeleton

Focal adhesion

Adherens junction

Tight junction

Regulation of actin cytoskeleton

4.97401 0.0096
32542_at FHL1 four and a half LIM domains 1   X 134955199 AF063002 Xq26 Hs.435369 14

molecular function unknown

nucleus

muscle development

zinc ion binding

cellular component unknown

organogenesis

cell growth

cell differentiation

metal ion binding

  4.95993 0.0102
40051_at TRAM2 translocation associated membrane protein 2   6 -52470158 D31762 6p21.1-p12 Hs.520182 5

protein targeting

protein transport

integral to membrane

  4.59002 0.0268
38032_at SV2A synaptic vesicle glycoprotein 2A   1 -146688307 AB018279 1q21.2 Hs.516153 5  

ECM-receptor interaction

4.53859 0.0308
39319_at LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)   5 -169607666 U20158 5q33.1-qter Hs.304475 39

protein binding

immune response

transmembrane receptor protein tyrosine kinase signaling pathway

intracellular signaling cascade

T cell receptor signaling pathway

4.5023 0.0346
33232_at CRIP1 cysteine-rich protein 1 (intestinal)   14 105024593 AI017574 14q32.33 Hs.70327 5

cytoplasm

zinc ion binding

cell proliferation

antimicrobial humoral response (sensu Vertebrata)

metal ion binding

  4.46321 0.0368
36591_at TUBA1 tubulin, alpha 1 (testis specific)   2 -219940505 X06956 2q35 Hs.75318 14

nucleotide binding

GTPase activity

structural molecule activity

protein binding

GTP binding

microtubule

microtubule-based movement

protein complex

protein polymerization

Gap junction

4.3714 0.0444
38994_at SOCS2 suppressor of cytokine signaling 2   12 92466065 AF037989 12q Hs.485572 18

regulation of cell growth

SH3/SH2 adaptor activity

growth hormone receptor binding

prolactin receptor binding

insulin-like growth factor receptor binding

protein binding

cytoplasm

anti-apoptosis

intracellular signaling cascade

JAK-STAT cascade

JAK pathway signal transduction adaptor activity

negative regulation of signal transduction

regulation of body size

positive regulation of neuron differentiation

Jak-STAT signaling pathway

Insulin signaling pathway

4.34612 0.0466
40076_at TPD52L2 tumor protein D52-like 2   20 61967033 AF004430 20q13.2-q13.3 Hs.473296 6

cell proliferation

  -4.33183 0.048

16 Genes