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- uncertainty in independent variables (e.g., in exposure estimate)
- attenuates regression coefficients
- doesn't properly incorporate uncertainty in final model
- what is the 'true' independent variable
- variable you want to regulate or manipulate?
- Solutions:
- joint models for covariates -> exposure -> health outcome
- two-stage models with uncertainty in exposure accounted for in health
outcome model
Chris Paciorek
2004-03-18