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Title: Basic microarray data questions
Speaker: Terry Speed
Place: Lorne Conference
Date: Feb. 11, 2000
Abstract:
The wealth of microarray-based gene
expression data now available
poses many questions ranging from
very basic ones such as finding the DNA
spots on the image and measuring
their intensities, through to
classifying genes and seeking to
elucidate biochemical pathways. Most
attention so far has been to clustering
methods for grouping genes
and/or samples. This talk will
focus on more basic issues such as
telling which genes' expression
levels are up, down or essentially
unchanged in treatment/control
comparisons, both within and across
experiments; assigning a precision
to measured intensity changes (on
the log scale); and whether different
ways of preprocessing the data
(spot identification, background
adjustment, color normalization) make
any discernible difference to the
foregoing.
Slides: Download [pdf files] [ps file]
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Last Updated March 07, 2000
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