A. Bureau, T. P. Speed
Week 9, Tuesday lecture: Monte Carlo methods in pedigree analysis
For any type of computation over pedigrees, the complexity of the task may increase to the point where exact computation is no longer feasible. Monte Carlo methods then provide alternatives to estimate the statistic or probability of interests. Markov chain Monte Carlo (MCMC) is one of the most useful simulation techniques in statistical genetics, and we begin by reviewing its principles.