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Title: Design of cDNA microarray experiments.

Authors: Yee Hwa Yang and Terry Speed

Abstract:

The objective of experimental design is to make the analysis of data and the interpretation of the results as simple and powerful as possible, while keeping the purpose of the experiment and the constraints of the experimental material clearly in mind. In cDNA microarray experiments, a popular design choice is to use a common reference sample in every experiment. This approach provides an easy means of comparing multiple samples against one another, as well as permitting the combination of results from different experiments. We will show in theory and with experimental data that the common reference approach is inherently more variable than direct comparison.

        
Slides: Download power point file [ppt file]