Stat 260: Statistics in Genetics

A. Bureau, S. Dudoit and T. P. Speed

Week 8, Tuesday lecture: Calculation of probabilities over pedigrees (2)

• Overview of the algorithms for computing probabilities over pedigrees
  • Simple peeling (Elston & Stewart)
  • Lander & Green HMM
  • Combining peeling and the Lander & Green HMM
• Allele recoding
  • The program VITESSE
• The power of multilocus mapping
  • Additional assumptions for HMM
  • Sib-pair multilocus analysis
  • Multilocus analysis on general pedigrees
  • Location scores
  • The HMM formulation of the location score
• Computing the probability of marker genotypes given an inheritance vector
• Yates' algorithm
• References
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