Stat 260: Statistics in Genetics

T. P. Speed, S. Cawley

Week 12: Finding Genes

• Introduction
• Biological details of the gene expression mechanism
  • Transcription
    • Promoter Sites
    • Termination Sites
    • Transcription Initiation
  • Translation
    • Some Idiosyncracies of Eukaryotic Sequence: Exons, Introns and Polyadenylation
  • Gene Structure
• Finding Genes
  • A first pass at locating genes
  • Using HMM's to model genetic sequence: prokaryotes
  • Using HMM's to model genetic sequence: eukaryotes
    • Locating splice sites
  • A brief introduction to some information theory
    • Applying Information Theory
• References
• About this document ...